HG10003456 (gene) Bottle gourd (Hangzhou Gourd) v1

Overview


Name	HG10003456
Type	gene
Organism	Lagenaria siceraria cv. Hangzhou Gourd (Bottle gourd (Hangzhou Gourd) v1)
Description	Protein DETOXIFICATION
Location	Chr08: 1638602 .. 1638883 (-)
RNA-Seq Expression	HG10003456
Synteny	HG10003456

Sequences

The following sequences are available for this feature:

Gene sequence (with intron)

Legend: CDSpolypeptide

Hold the cursor over a type above to highlight its positions in the sequence below.

ATGTGTTTGTTTGGTGAGAAAATGAGAGAAAATTGGTGGGTTGTTTATAGAAAAGAGGTGAAGAAAGTGAGCTTCATAGCAGCTCCAATGGCTGCCAGCGCCACTTTGCAATATGGAATGCAAATTGTTGCAGTGATTATGGTTGGACATCTTGGAGATGAGCTTTTGCTTTCTGGAGTTTCCATTGCTTCATCCGTCATCAATGTCACTGGATGTAGTGTTCTTGTAAGTCCTTTTCTTTTTAATAGTTCCTTCTTAGTTTATATCATTTTAAATGTGTAA

mRNA sequence

ATGTGTTTGTTTGGTGAGAAAATGAGAGAAAATTGGTGGGTTGTTTATAGAAAAGAGGTGAAGAAAGTGAGCTTCATAGCAGCTCCAATGGCTGCCAGCGCCACTTTGCAATATGGAATGCAAATTGTTGCAGTGATTATGGTTGGACATCTTGGAGATGAGCTTTTGCTTTCTGGAGTTTCCATTGCTTCATCCGTCATCAATGTCACTGGATGTAGTGTTCTTGTAAGTCCTTTTCTTTTTAATAGTTCCTTCTTAGTTTATATCATTTTAAATGTGTAA

Coding sequence (CDS)

ATGTGTTTGTTTGGTGAGAAAATGAGAGAAAATTGGTGGGTTGTTTATAGAAAAGAGGTGAAGAAAGTGAGCTTCATAGCAGCTCCAATGGCTGCCAGCGCCACTTTGCAATATGGAATGCAAATTGTTGCAGTGATTATGGTTGGACATCTTGGAGATGAGCTTTTGCTTTCTGGAGTTTCCATTGCTTCATCCGTCATCAATGTCACTGGATGTAGTGTTCTTGTAAGTCCTTTTCTTTTTAATAGTTCCTTCTTAGTTTATATCATTTTAAATGTGTAA

Protein sequence

MCLFGEKMRENWWVVYRKEVKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGVSIASSVINVTGCSVLVSPFLFNSSFLVYIILNV

Homology

[Close]

BLAST of HG10003456 vs. NCBI nr
Match: XP_038889425.1 (protein DETOXIFICATION 3-like isoform X1 [Benincasa hispida])

HSP 1 Score: 131.0 bits (328), Expect = 5.5e-27
Identity = 68/76 (89.47%), Postives = 72/76 (94.74%), Query Frame = 0


Query: 1  MCLFGEKMRENWWVVYRKEVKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGV 60
          MCLFGEKMRENWW VYRKE+KKVSFIAAPMAAS  LQYGMQIV+V+MVGHLGDELLLSGV
Sbjct: 1  MCLFGEKMRENWW-VYRKELKKVSFIAAPMAASTILQYGMQIVSVMMVGHLGDELLLSGV 60

Query: 61 SIASSVINVTGCSVLV 77
          SIASS INVTGCSVL+
Sbjct: 61 SIASSFINVTGCSVLL 75

[Close]

BLAST of HG10003456 vs. NCBI nr
Match: KAA0039279.1 (protein DETOXIFICATION 12-like isoform X3 [Cucumis melo var. makuwa] >TYK00464.1 protein DETOXIFICATION 12-like isoform X3 [Cucumis melo var. makuwa])

HSP 1 Score: 107.5 bits (267), Expect = 6.5e-20
Identity = 61/81 (75.31%), Postives = 66/81 (81.48%), Query Frame = 0


Query: 8  MRENWWVVYRKEVKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGVSIASSVI 67
          MRE  W VYRKE+K V F+AAPMAAS  LQYGMQ V V+MVGHLGDELLLSG+SIASS I
Sbjct: 1  MREKLW-VYRKELKTVIFMAAPMAASTILQYGMQTVGVMMVGHLGDELLLSGLSIASSFI 60

Query: 68 NVTGCSVLVSPFLFNSSFLVY 89
          NVTGCSVLVSPFL  +  L Y
Sbjct: 61 NVTGCSVLVSPFLSVTLSLAY 80

[Close]

BLAST of HG10003456 vs. NCBI nr
Match: XP_004141549.1 (protein DETOXIFICATION 12 isoform X2 [Cucumis sativus])

HSP 1 Score: 105.5 bits (262), Expect = 2.5e-19
Identity = 57/69 (82.61%), Postives = 62/69 (89.86%), Query Frame = 0


Query: 8  MRENWWVVYRKEVKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGVSIASSVI 67
          MRE  W VYRKE+KKVSFIAAP+AAS  LQYGMQIV V+MVGHLGDELLLSG+SIASS I
Sbjct: 1  MREKLW-VYRKELKKVSFIAAPLAASTVLQYGMQIVGVMMVGHLGDELLLSGLSIASSFI 60

Query: 68 NVTGCSVLV 77
          NVTGCSVL+
Sbjct: 61 NVTGCSVLL 68

[Close]

BLAST of HG10003456 vs. NCBI nr
Match: XP_022925515.1 (protein DETOXIFICATION 3-like isoform X2 [Cucurbita moschata])

HSP 1 Score: 104.0 bits (258), Expect = 7.2e-19
Identity = 56/69 (81.16%), Postives = 60/69 (86.96%), Query Frame = 0


Query: 8  MRENWWVVYRKEVKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGVSIASSVI 67
          MRENW+ VYRKEVKKV  IAAPMAA+  LQY MQ+VAVIMVGHLGDELLLSGVSIASS  
Sbjct: 1  MRENWFRVYRKEVKKVILIAAPMAATTILQYAMQVVAVIMVGHLGDELLLSGVSIASSFT 60

Query: 68 NVTGCSVLV 77
          NVTG SVL+
Sbjct: 61 NVTGISVLL 69

[Close]

BLAST of HG10003456 vs. NCBI nr
Match: XP_022141870.1 (protein DETOXIFICATION 3-like isoform X4 [Momordica charantia])

HSP 1 Score: 103.6 bits (257), Expect = 9.4e-19
Identity = 56/69 (81.16%), Postives = 61/69 (88.41%), Query Frame = 0


Query: 8  MRENWWVVYRKEVKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGVSIASSVI 67
          MRENWW VYRKEVKKVS IAAPMAAS  LQY MQIVAV+MVGHLGD+LLLSG SIA+S +
Sbjct: 1  MRENWW-VYRKEVKKVSLIAAPMAASTILQYSMQIVAVMMVGHLGDQLLLSGGSIATSFV 60

Query: 68 NVTGCSVLV 77
          NVTG SVL+
Sbjct: 61 NVTGISVLL 68

[Close]

BLAST of HG10003456 vs. ExPASy Swiss-Prot
Match: F4HQ05 (Protein DETOXIFICATION 8 OS=Arabidopsis thaliana OX=3702 GN=DTX8 PE=3 SV=1)

HSP 1 Score: 59.3 bits (142), Expect = 2.7e-08
Identity = 32/56 (57.14%), Postives = 45/56 (80.36%), Query Frame = 0


Query: 20 VKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGVSIASSVINVTGCSVL 76
          +KKVSF+AAPM A A  QY +Q+++++M GHL DEL LS V+IA+S+ NVTG S++
Sbjct: 36 MKKVSFMAAPMVAVAASQYLLQVISIVMAGHL-DELSLSAVAIATSLTNVTGFSLI 90

[Close]

BLAST of HG10003456 vs. ExPASy Swiss-Prot
Match: Q9SIA1 (Protein DETOXIFICATION 5 OS=Arabidopsis thaliana OX=3702 GN=DTX5 PE=3 SV=2)

HSP 1 Score: 54.7 bits (130), Expect = 6.5e-07
Identity = 28/69 (40.58%), Postives = 45/69 (65.22%), Query Frame = 0


Query: 7  KMRENWWVVYRKEVKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGVSIASSV 66
          K    WW+ +  E+K VS +AAPMA     QY + +++V++ GH G EL LSGV++A++ 
Sbjct: 18 KSTPTWWMNFTAELKNVSSMAAPMATVTVSQYLLPVISVMVAGHCG-ELQLSGVTLATAF 77

Query: 67 INVTGCSVL 76
           NV+G  ++
Sbjct: 78 ANVSGFGIM 85

[Close]

BLAST of HG10003456 vs. ExPASy Swiss-Prot
Match: Q1PFG9 (Protein DETOXIFICATION 7 OS=Arabidopsis thaliana OX=3702 GN=DTX7 PE=2 SV=1)

HSP 1 Score: 53.9 bits (128), Expect = 1.1e-06
Identity = 30/57 (52.63%), Postives = 45/57 (78.95%), Query Frame = 0


Query: 20 VKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGVSIASSVINVTGCSVLV 77
          +KKVS +AAPM A +  Q+ +Q+++++M GHL DEL LS V+IA+S+ NVTG S++V
Sbjct: 30 MKKVSSMAAPMVAVSVSQFLLQVISMVMAGHL-DELSLSAVAIATSLTNVTGFSLIV 85

[Close]

BLAST of HG10003456 vs. ExPASy Swiss-Prot
Match: Q8L731 (Protein DETOXIFICATION 12 OS=Arabidopsis thaliana OX=3702 GN=DTX12 PE=2 SV=1)

HSP 1 Score: 52.4 bits (124), Expect = 3.3e-06
Identity = 30/58 (51.72%), Postives = 43/58 (74.14%), Query Frame = 0


Query: 19 EVKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGVSIASSVINVTGCSVLV 77
          E+K++ F AAPMAA    Q+ +QIV+++MVGHLG+ L L+  S+ASS  NVTG S ++
Sbjct: 34 ELKRLIFFAAPMAAVVIAQFMLQIVSMMMVGHLGN-LSLASASLASSFCNVTGFSFII 90

[Close]

BLAST of HG10003456 vs. ExPASy Swiss-Prot
Match: Q9C994 (Protein DETOXIFICATION 14 OS=Arabidopsis thaliana OX=3702 GN=DTX14 PE=1 SV=1)

HSP 1 Score: 52.4 bits (124), Expect = 3.3e-06
Identity = 29/60 (48.33%), Postives = 43/60 (71.67%), Query Frame = 0


Query: 16 YRKEVKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGVSIASSVINVTGCSVL 75
          + +E KK+S+IA PM A  +  Y +Q+++++MVGHLG EL LS  +IA S  +VTG SV+
Sbjct: 23 FLRETKKLSYIAGPMIAVNSSMYVLQVISIMMVGHLG-ELFLSSTAIAVSFCSVTGFSVV 81

[Close]

BLAST of HG10003456 vs. ExPASy TrEMBL
Match: A0A5A7TDD2 (Protein DETOXIFICATION 12-like isoform X3 OS=Cucumis melo var. makuwa OX=1194695 GN=E5676_scaffold169G00690 PE=4 SV=1)

HSP 1 Score: 107.5 bits (267), Expect = 3.1e-20
Identity = 61/81 (75.31%), Postives = 66/81 (81.48%), Query Frame = 0


Query: 8  MRENWWVVYRKEVKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGVSIASSVI 67
          MRE  W VYRKE+K V F+AAPMAAS  LQYGMQ V V+MVGHLGDELLLSG+SIASS I
Sbjct: 1  MREKLW-VYRKELKTVIFMAAPMAASTILQYGMQTVGVMMVGHLGDELLLSGLSIASSFI 60

Query: 68 NVTGCSVLVSPFLFNSSFLVY 89
          NVTGCSVLVSPFL  +  L Y
Sbjct: 61 NVTGCSVLVSPFLSVTLSLAY 80

[Close]

BLAST of HG10003456 vs. ExPASy TrEMBL
Match: A0A0A0KST7 (Protein DETOXIFICATION OS=Cucumis sativus OX=3659 GN=Csa_5G649880 PE=3 SV=1)

HSP 1 Score: 105.5 bits (262), Expect = 1.2e-19
Identity = 57/69 (82.61%), Postives = 62/69 (89.86%), Query Frame = 0


Query: 8  MRENWWVVYRKEVKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGVSIASSVI 67
          MRE  W VYRKE+KKVSFIAAP+AAS  LQYGMQIV V+MVGHLGDELLLSG+SIASS I
Sbjct: 1  MREKLW-VYRKELKKVSFIAAPLAASTVLQYGMQIVGVMMVGHLGDELLLSGLSIASSFI 60

Query: 68 NVTGCSVLV 77
          NVTGCSVL+
Sbjct: 61 NVTGCSVLL 68

[Close]

BLAST of HG10003456 vs. ExPASy TrEMBL
Match: A0A6J1EI79 (Protein DETOXIFICATION OS=Cucurbita moschata OX=3662 GN=LOC111432792 PE=3 SV=1)

HSP 1 Score: 104.0 bits (258), Expect = 3.5e-19
Identity = 56/69 (81.16%), Postives = 60/69 (86.96%), Query Frame = 0


Query: 8  MRENWWVVYRKEVKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGVSIASSVI 67
          MRENW+ VYRKEVKKV  IAAPMAA+  LQY MQ+VAVIMVGHLGDELLLSGVSIASS  
Sbjct: 1  MRENWFRVYRKEVKKVILIAAPMAATTILQYAMQVVAVIMVGHLGDELLLSGVSIASSFT 60

Query: 68 NVTGCSVLV 77
          NVTG SVL+
Sbjct: 61 NVTGISVLL 69

[Close]

BLAST of HG10003456 vs. ExPASy TrEMBL
Match: A0A6J1CJB5 (Protein DETOXIFICATION OS=Momordica charantia OX=3673 GN=LOC111012127 PE=3 SV=1)

HSP 1 Score: 103.6 bits (257), Expect = 4.5e-19
Identity = 56/69 (81.16%), Postives = 61/69 (88.41%), Query Frame = 0


Query: 8  MRENWWVVYRKEVKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGVSIASSVI 67
          MRENWW VYRKEVKKVS IAAPMAAS  LQY MQIVAV+MVGHLGD+LLLSG SIA+S +
Sbjct: 1  MRENWW-VYRKEVKKVSLIAAPMAASTILQYSMQIVAVMMVGHLGDQLLLSGGSIATSFV 60

Query: 68 NVTGCSVLV 77
          NVTG SVL+
Sbjct: 61 NVTGISVLL 68

[Close]

BLAST of HG10003456 vs. ExPASy TrEMBL
Match: A0A6J1I8X8 (Protein DETOXIFICATION OS=Cucurbita maxima OX=3661 GN=LOC111472575 PE=3 SV=1)

HSP 1 Score: 101.3 bits (251), Expect = 2.3e-18
Identity = 53/69 (76.81%), Postives = 60/69 (86.96%), Query Frame = 0


Query: 8  MRENWWVVYRKEVKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGVSIASSVI 67
          MRENW+ VY+KE+KKV  IAAPMAA+  LQY MQ+VAVIMVGHLGDELLLSGVSIASS  
Sbjct: 1  MRENWFRVYKKELKKVMLIAAPMAATTILQYAMQVVAVIMVGHLGDELLLSGVSIASSFT 60

Query: 68 NVTGCSVLV 77
          NVTG SV++
Sbjct: 61 NVTGISVIL 69

[Close]

BLAST of HG10003456 vs. TAIR 10
Match: AT1G66780.1 (MATE efflux family protein )

HSP 1 Score: 59.3 bits (142), Expect = 1.9e-09
Identity = 32/56 (57.14%), Postives = 45/56 (80.36%), Query Frame = 0


Query: 20 VKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGVSIASSVINVTGCSVL 76
          +KKVSF+AAPM A A  QY +Q+++++M GHL DEL LS V+IA+S+ NVTG S++
Sbjct: 36 MKKVSFMAAPMVAVAASQYLLQVISIVMAGHL-DELSLSAVAIATSLTNVTGFSLI 90

[Close]

BLAST of HG10003456 vs. TAIR 10
Match: AT2G04090.1 (MATE efflux family protein )

HSP 1 Score: 54.7 bits (130), Expect = 4.7e-08
Identity = 28/69 (40.58%), Postives = 45/69 (65.22%), Query Frame = 0


Query: 7  KMRENWWVVYRKEVKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGVSIASSV 66
          K    WW+ +  E+K VS +AAPMA     QY + +++V++ GH G EL LSGV++A++ 
Sbjct: 18 KSTPTWWMNFTAELKNVSSMAAPMATVTVSQYLLPVISVMVAGHCG-ELQLSGVTLATAF 77

Query: 67 INVTGCSVL 76
           NV+G  ++
Sbjct: 78 ANVSGFGIM 85

[Close]

BLAST of HG10003456 vs. TAIR 10
Match: AT1G64820.1 (MATE efflux family protein )

HSP 1 Score: 53.9 bits (128), Expect = 7.9e-08
Identity = 30/57 (52.63%), Postives = 45/57 (78.95%), Query Frame = 0


Query: 20 VKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGVSIASSVINVTGCSVLV 77
          +KKVS +AAPM A +  Q+ +Q+++++M GHL DEL LS V+IA+S+ NVTG S++V
Sbjct: 30 MKKVSSMAAPMVAVSVSQFLLQVISMVMAGHL-DELSLSAVAIATSLTNVTGFSLIV 85

[Close]

BLAST of HG10003456 vs. TAIR 10
Match: AT1G15170.1 (MATE efflux family protein )

HSP 1 Score: 52.4 bits (124), Expect = 2.3e-07
Identity = 30/58 (51.72%), Postives = 43/58 (74.14%), Query Frame = 0


Query: 19 EVKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGVSIASSVINVTGCSVLV 77
          E+K++ F AAPMAA    Q+ +QIV+++MVGHLG+ L L+  S+ASS  NVTG S ++
Sbjct: 34 ELKRLIFFAAPMAAVVIAQFMLQIVSMMMVGHLGN-LSLASASLASSFCNVTGFSFII 90

[Close]

BLAST of HG10003456 vs. TAIR 10
Match: AT1G71140.1 (MATE efflux family protein )

HSP 1 Score: 52.4 bits (124), Expect = 2.3e-07
Identity = 29/60 (48.33%), Postives = 43/60 (71.67%), Query Frame = 0


Query: 16 YRKEVKKVSFIAAPMAASATLQYGMQIVAVIMVGHLGDELLLSGVSIASSVINVTGCSVL 75
          + +E KK+S+IA PM A  +  Y +Q+++++MVGHLG EL LS  +IA S  +VTG SV+
Sbjct: 23 FLRETKKLSYIAGPMIAVNSSMYVLQVISIMMVGHLG-ELFLSSTAIAVSFCSVTGFSVV 81

The following BLAST results are available for this feature:

BLAST of HG10003456 vs. NCBI nr


Match Name	E-value	Identity	Description
XP_038889425.1	5.5e-27	89.47	protein DETOXIFICATION 3-like isoform X1 [Benincasa hispida]	[more]
KAA0039279.1	6.5e-20	75.31	protein DETOXIFICATION 12-like isoform X3 [Cucumis melo var. makuwa] >TYK00464.1...	[more]
XP_004141549.1	2.5e-19	82.61	protein DETOXIFICATION 12 isoform X2 [Cucumis sativus]	[more]
XP_022925515.1	7.2e-19	81.16	protein DETOXIFICATION 3-like isoform X2 [Cucurbita moschata]	[more]
XP_022141870.1	9.4e-19	81.16	protein DETOXIFICATION 3-like isoform X4 [Momordica charantia]	[more]

BLAST of HG10003456 vs. ExPASy Swiss-Prot


Match Name	E-value	Identity	Description
F4HQ05	2.7e-08	57.14	Protein DETOXIFICATION 8 OS=Arabidopsis thaliana OX=3702 GN=DTX8 PE=3 SV=1	[more]
Q9SIA1	6.5e-07	40.58	Protein DETOXIFICATION 5 OS=Arabidopsis thaliana OX=3702 GN=DTX5 PE=3 SV=2	[more]
Q1PFG9	1.1e-06	52.63	Protein DETOXIFICATION 7 OS=Arabidopsis thaliana OX=3702 GN=DTX7 PE=2 SV=1	[more]
Q8L731	3.3e-06	51.72	Protein DETOXIFICATION 12 OS=Arabidopsis thaliana OX=3702 GN=DTX12 PE=2 SV=1	[more]
Q9C994	3.3e-06	48.33	Protein DETOXIFICATION 14 OS=Arabidopsis thaliana OX=3702 GN=DTX14 PE=1 SV=1	[more]

BLAST of HG10003456 vs. ExPASy TrEMBL


Match Name	E-value	Identity	Description
A0A5A7TDD2	3.1e-20	75.31	Protein DETOXIFICATION 12-like isoform X3 OS=Cucumis melo var. makuwa OX=1194695...	[more]
A0A0A0KST7	1.2e-19	82.61	Protein DETOXIFICATION OS=Cucumis sativus OX=3659 GN=Csa_5G649880 PE=3 SV=1	[more]
A0A6J1EI79	3.5e-19	81.16	Protein DETOXIFICATION OS=Cucurbita moschata OX=3662 GN=LOC111432792 PE=3 SV=1	[more]
A0A6J1CJB5	4.5e-19	81.16	Protein DETOXIFICATION OS=Momordica charantia OX=3673 GN=LOC111012127 PE=3 SV=1	[more]
A0A6J1I8X8	2.3e-18	76.81	Protein DETOXIFICATION OS=Cucurbita maxima OX=3661 GN=LOC111472575 PE=3 SV=1	[more]

BLAST of HG10003456 vs. TAIR 10


Match Name	E-value	Identity	Description
AT1G66780.1	1.9e-09	57.14	MATE efflux family protein	[more]
AT2G04090.1	4.7e-08	40.58	MATE efflux family protein	[more]
AT1G64820.1	7.9e-08	52.63	MATE efflux family protein	[more]
AT1G15170.1	2.3e-07	51.72	MATE efflux family protein	[more]
AT1G71140.1	2.3e-07	48.33	MATE efflux family protein	[more]

InterPro

Analysis Name: InterPro Annotations of Bottle gourd (Hangzhou Gourd) v1
Date Performed: 2022-08-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	PANTHER	PTHR11206:SF345	PROTEIN DETOXIFICATION	coord: 18..75
None	No IPR available	PANTHER	PTHR11206	MULTIDRUG RESISTANCE PROTEIN	coord: 18..75

Relationships

The following mRNA feature(s) are a part of this gene:


Feature Name	Unique Name	Type
HG10003456.1	HG10003456.1	mRNA

GO Annotation

GO Assignments

This gene is annotated with the following GO terms.

Category	Term Accession	Term Name
biological_process	GO:1990961	xenobiotic detoxification by transmembrane export across the plasma membrane
cellular_component	GO:0016021	integral component of membrane
molecular_function	GO:0015297	antiporter activity
molecular_function	GO:0042910	xenobiotic transmembrane transporter activity