CmaCh08G000240 (gene) Cucurbita maxima (Rimu) v1.1

Overview
NameCmaCh08G000240
Typegene
OrganismCucurbita maxima (Cucurbita maxima (Rimu) v1.1)
Descriptiontrihelix transcription factor ASR3-like isoform X1
LocationCma_Chr08: 135070 .. 137496 (-)
RNA-Seq ExpressionCmaCh08G000240
SyntenyCmaCh08G000240
Sequences
The following sequences are available for this feature:

Gene sequence (with intron)

Legend: exonfive_prime_UTRpolypeptideCDSthree_prime_UTR
Hold the cursor over a type above to highlight its positions in the sequence below.
GAGATGATCTGACAAACTGAATCCCAAACGCCGTAACGGACCCTCCCTAAACATCCCCGTTTACGCCTTCCCAAAACCATTCTCCAATCTCCATTAAGTCACGTGCTCTTCTTCTTAACAATATTCTTATCATTTTTCTTTTTCTTTTTCTTTTCCCTCTTTATATTTATATGGCTTTGCAGCAGCTTACCCTTGGCCCAACTCCCGTTCACGCCGTTTCCGACGCCGTCACTAATGCCCTTGACGCCCGCCCCATCTCATCTGACGGCGGAGACAACGGCAGCAAAACCCCCAGGCTCCCCCGTTGGACCCGCCAGGAGATTCTCGTCCTCATACAGGGCAAGAAGGTTGCTGAGACCAGGGTTCGCGGAGGCCGGGCCGCTACTCTCGCCTTTGGTTCCGCCCAGCTCGAGCCCAAGTGGGCCTCTGTCTCCTCCTACTGTAAGAGGCATGGGGTTAATCGGGGTCCGGTTCAGTGCCGCAAGAGATGGAGCAATTTGGCTGGCGACTTCAAGAAGATCAAGGACTGGGAGTCCCAAATTAGGGATGACTCTGAATCCTTTTGGGTCACGAGGAACGATTTGAGGCGCGAGAGGAAATTGCCAGGGTTTTTCGACAGAGAGGTTTATGATATCTTGGAATCCGGCTCGGCTCCTTCGCCGTCGCCGACTCTGGCTCTCGCCCTCGCTCCTGCTCCTGCTCCTGCTCCTCCTCCTCCTCCTCCTCCTCCGGTCCCCACTCTCACGTCAGCCCTAAATTCCGATGACGCCGAGCCGGAGCACGTCTTCGATAGTTTTAAAACTGCGGCAGCGGACGACGGCTTGTTTTCCGATTTCGAGCAGGACGAAACCAGCCAGAGCCCCATCAAGGAGGTCCCGGGGAAGGAGGCTCCGGTCCCGACGCTCGACGAGGAAATTCCTGCTCCGGCACCTTTATCAGGTAATTGGAGAAGAAGGGTCAAATTCAAATCTCTCTCTATTTGTTTAATTCAACCTGCGTGGTCTCCAAATAATGATAACCTGCGTGGTCTCCAAAAGATCCGGTCTCAAAAAATTAAATGACAACTCTTCCTGGTTGTTTCGAGATTCTTGCAGCTTATGTGGCAATTATTCTTTTCTCCTTCCACCCTTCTTAAAAAACCATTTTATATGTTCGGTCGGCTTCGAAGAAGATTTGAAGCTCCATTTTATCTCTAGTTTCAATTTCTTTCCCCTTGATTTACAGAGAAGCTGTACCAACCTGCTAGTCAAGGTTGTCCTGATCAAGGTAAGCTCAAAGTACAATTCGAATACATATTCATTCTGGGATTCTGTTGTAAACCCTTCCTTCAGACACAAATATTTGTTCATAATCATTGTGGTCGTTTGATGGTTCAACCTTTCATTTAGAGGATGAAAGAATATCTCTGGTGCTGTTGCACGCCTACGCCTATGTTCATTAGCTGCAAAGATTAGTTCTTTTTTGTCTTCTCAATTCCGGATGAATAATGAAGTCAATAAAGCACTATCTTCTTATATTGTTGATTTGATATGCTTTATCTTGTGCGCTTCAAATTTTCAGTCAGAATCCCTTTTTTGGTACCCACTAAGCTTTTGTGTCTGTACGTTCGTGAATCCTATTGTTTTTACCCCTCCCCCTCCTTTCCATTACGAGCGTCGCAGTTTCAAAATTCAGCTGGCGCTGCGAATCTGTTTTGTGTGGTCAAAGTTTGAGTGTCCGTTCTGTGAAGGCTCAAAAACTTGGGATCAAAATCTTGTTAGAGGTGTTGTTTAGTTGGGTTTGGGAAGCTTCAGAGTCCAACATTATGAAGACGGATGCCTGTTTTATTTTTTTTTTGTTGGTGTTCTGAATCCCCAAATTGTTGGCAAGAGTGGAGACAATAATAACTTATTGTGAGCCCAATCTGGTGTGCAACAGGCACGTCAAATGAGAGAGAGGCAGCAGCAAATCCGGAGATAGGATCGAGTTTGCAAGAGGGACGGAAGCGGAAGCGCATGGCAAAAGAGGGGGAGGAGGAAAGTATGATGGTGCAGGATGAGTTGATTGGCATCCTGGAAAAGAATGGGAAACTGCTGACTGCCCAACTTGAAGCTCAAAACATGAACTTCCAGCTGGACCGGGAGCAGCGAAGATACCACGCAGATGGGCTAGTGACGGTTCTGAACAAGCTCGCAGATGCTCTAGGCAGGATCGCGGATAAGCTGTAGAACAAGAAGCAGGCAGGGCAGATGAGTAGATGTGTACATAAGCAGCAGCAGCAACGTGTATGTGCCTTTTTATGACGACGGCCAAATTAGTGGAGAGTAGAATTTACGTAGGTTGCCCCATACACAGATAAGAGTTGATATCTGACCACATTTCATTTTCTGCTATATTTGTAAATCTTTATTATTATTTTATTTTCATAAAGACGCATTTGCCTCGTTC

mRNA sequence

GAGATGATCTGACAAACTGAATCCCAAACGCCGTAACGGACCCTCCCTAAACATCCCCGTTTACGCCTTCCCAAAACCATTCTCCAATCTCCATTAAGTCACGTGCTCTTCTTCTTAACAATATTCTTATCATTTTTCTTTTTCTTTTTCTTTTCCCTCTTTATATTTATATGGCTTTGCAGCAGCTTACCCTTGGCCCAACTCCCGTTCACGCCGTTTCCGACGCCGTCACTAATGCCCTTGACGCCCGCCCCATCTCATCTGACGGCGGAGACAACGGCAGCAAAACCCCCAGGCTCCCCCGTTGGACCCGCCAGGAGATTCTCGTCCTCATACAGGGCAAGAAGGTTGCTGAGACCAGGGTTCGCGGAGGCCGGGCCGCTACTCTCGCCTTTGGTTCCGCCCAGCTCGAGCCCAAGTGGGCCTCTGTCTCCTCCTACTGTAAGAGGCATGGGGTTAATCGGGGTCCGGTTCAGTGCCGCAAGAGATGGAGCAATTTGGCTGGCGACTTCAAGAAGATCAAGGACTGGGAGTCCCAAATTAGGGATGACTCTGAATCCTTTTGGGTCACGAGGAACGATTTGAGGCGCGAGAGGAAATTGCCAGGGTTTTTCGACAGAGAGGTTTATGATATCTTGGAATCCGGCTCGGCTCCTTCGCCGTCGCCGACTCTGGCTCTCGCCCTCGCTCCTGCTCCTGCTCCTGCTCCTCCTCCTCCTCCTCCTCCTCCGGTCCCCACTCTCACGTCAGCCCTAAATTCCGATGACGCCGAGCCGGAGCACGTCTTCGATAGTTTTAAAACTGCGGCAGCGGACGACGGCTTGTTTTCCGATTTCGAGCAGGACGAAACCAGCCAGAGCCCCATCAAGGAGGTCCCGGGGAAGGAGGCTCCGGTCCCGACGCTCGACGAGGAAATTCCTGCTCCGGCACCTTTATCAGAGAAGCTGTACCAACCTGCTAGTCAAGGTTGTCCTGATCAAGGCACGTCAAATGAGAGAGAGGCAGCAGCAAATCCGGAGATAGGATCGAGTTTGCAAGAGGGACGGAAGCGGAAGCGCATGGCAAAAGAGGGGGAGGAGGAAAGTATGATGGTGCAGGATGAGTTGATTGGCATCCTGGAAAAGAATGGGAAACTGCTGACTGCCCAACTTGAAGCTCAAAACATGAACTTCCAGCTGGACCGGGAGCAGCGAAGATACCACGCAGATGGGCTAGTGACGGTTCTGAACAAGCTCGCAGATGCTCTAGGCAGGATCGCGGATAAGCTGTAGAACAAGAAGCAGGCAGGGCAGATGAGTAGATGTGTACATAAGCAGCAGCAGCAACGTGTATGTGCCTTTTTATGACGACGGCCAAATTAGTGGAGAGTAGAATTTACGTAGGTTGCCCCATACACAGATAAGAGTTGATATCTGACCACATTTCATTTTCTGCTATATTTGTAAATCTTTATTATTATTTTATTTTCATAAAGACGCATTTGCCTCGTTC

Coding sequence (CDS)

ATGGCTTTGCAGCAGCTTACCCTTGGCCCAACTCCCGTTCACGCCGTTTCCGACGCCGTCACTAATGCCCTTGACGCCCGCCCCATCTCATCTGACGGCGGAGACAACGGCAGCAAAACCCCCAGGCTCCCCCGTTGGACCCGCCAGGAGATTCTCGTCCTCATACAGGGCAAGAAGGTTGCTGAGACCAGGGTTCGCGGAGGCCGGGCCGCTACTCTCGCCTTTGGTTCCGCCCAGCTCGAGCCCAAGTGGGCCTCTGTCTCCTCCTACTGTAAGAGGCATGGGGTTAATCGGGGTCCGGTTCAGTGCCGCAAGAGATGGAGCAATTTGGCTGGCGACTTCAAGAAGATCAAGGACTGGGAGTCCCAAATTAGGGATGACTCTGAATCCTTTTGGGTCACGAGGAACGATTTGAGGCGCGAGAGGAAATTGCCAGGGTTTTTCGACAGAGAGGTTTATGATATCTTGGAATCCGGCTCGGCTCCTTCGCCGTCGCCGACTCTGGCTCTCGCCCTCGCTCCTGCTCCTGCTCCTGCTCCTCCTCCTCCTCCTCCTCCTCCGGTCCCCACTCTCACGTCAGCCCTAAATTCCGATGACGCCGAGCCGGAGCACGTCTTCGATAGTTTTAAAACTGCGGCAGCGGACGACGGCTTGTTTTCCGATTTCGAGCAGGACGAAACCAGCCAGAGCCCCATCAAGGAGGTCCCGGGGAAGGAGGCTCCGGTCCCGACGCTCGACGAGGAAATTCCTGCTCCGGCACCTTTATCAGAGAAGCTGTACCAACCTGCTAGTCAAGGTTGTCCTGATCAAGGCACGTCAAATGAGAGAGAGGCAGCAGCAAATCCGGAGATAGGATCGAGTTTGCAAGAGGGACGGAAGCGGAAGCGCATGGCAAAAGAGGGGGAGGAGGAAAGTATGATGGTGCAGGATGAGTTGATTGGCATCCTGGAAAAGAATGGGAAACTGCTGACTGCCCAACTTGAAGCTCAAAACATGAACTTCCAGCTGGACCGGGAGCAGCGAAGATACCACGCAGATGGGCTAGTGACGGTTCTGAACAAGCTCGCAGATGCTCTAGGCAGGATCGCGGATAAGCTGTAG

Protein sequence

MALQQLTLGPTPVHAVSDAVTNALDARPISSDGGDNGSKTPRLPRWTRQEILVLIQGKKVAETRVRGGRAATLAFGSAQLEPKWASVSSYCKRHGVNRGPVQCRKRWSNLAGDFKKIKDWESQIRDDSESFWVTRNDLRRERKLPGFFDREVYDILESGSAPSPSPTLALALAPAPAPAPPPPPPPPVPTLTSALNSDDAEPEHVFDSFKTAAADDGLFSDFEQDETSQSPIKEVPGKEAPVPTLDEEIPAPAPLSEKLYQPASQGCPDQGTSNEREAAANPEIGSSLQEGRKRKRMAKEGEEESMMVQDELIGILEKNGKLLTAQLEAQNMNFQLDREQRRYHADGLVTVLNKLADALGRIADKL
Homology
BLAST of CmaCh08G000240 vs. ExPASy Swiss-Prot
Match: Q8VZ20 (Trihelix transcription factor ASR3 OS=Arabidopsis thaliana OX=3702 GN=ASR3 PE=1 SV=1)

HSP 1 Score: 322.8 bits (826), Expect = 5.1e-87
Identity = 191/374 (51.07%), Postives = 240/374 (64.17%), Query Frame = 0

Query: 1   MALQQLTLGPTPVHAVSDAVTNALDARPISSDGGDNGSKTPRLPRWTRQEILVLIQGKKV 60
           MAL+QL LG +       AV    ++   S+DGGD+G KT RLPRWTRQEILVLIQGK+V
Sbjct: 1   MALEQLGLGVS-------AVDGGENSSAPSNDGGDDGVKTARLPRWTRQEILVLIQGKRV 60

Query: 61  AETRVRGGRAATLAFGSAQLEPKWASVSSYCKRHGVNRGPVQCRKRWSNLAGDFKKIKDW 120
           AE RVR GRAA +A GS Q+EPKWASVSSYCKRHGVNRGPVQCRKRWSNLAGD+KKIK+W
Sbjct: 61  AENRVRRGRAAGMALGSGQMEPKWASVSSYCKRHGVNRGPVQCRKRWSNLAGDYKKIKEW 120

Query: 121 ESQIRDDSESFWVTRNDLRRERKLPGFFDREVYDILESGSAPSPSPTLALALAPAPAPAP 180
           ESQI++++ES+WV RND+RRE+KLPGFFD+EVYDI++ G  P   P L+L LAP      
Sbjct: 121 ESQIKEETESYWVMRNDVRREKKLPGFFDKEVYDIVDGGVIPPAVPVLSLGLAP------ 180

Query: 181 PPPPPPPVPTLTSALNSDDAEPEHVFDSFKTAAADDGLFSDFEQDETSQSPIKEVPGKEA 240
                                           A+D+GL SD ++ E S   +   P  ++
Sbjct: 181 --------------------------------ASDEGLLSDLDRRE-SPEKLNSTPVAKS 240

Query: 241 PVPTLDEEIPAPAPLSEKLYQPASQGC-PDQGTSNERE-AAANPEIGSSLQEGRKRKRMA 300
               +D+E                + C  DQG   E++  AAN E GS+ QE RKRKR +
Sbjct: 241 VTDVIDKE--------------KQEACVADQGRVKEKQPEAANVEGGSTSQEERKRKRTS 300

Query: 301 ------KEGEEESMMVQDELIGILEKNGKLLTAQLEAQNMNFQLDREQRRYHADGLVTVL 360
                 +E E E+  +Q++LI ILE+NG+LL AQLE QN+N +LDREQR+ H D LV VL
Sbjct: 301 FGEKEEEEEEGETKKMQNQLIEILERNGQLLAAQLEVQNLNLKLDREQRKDHGDSLVAVL 314

Query: 361 NKLADALGRIADKL 367
           NKLADA+ +IADK+
Sbjct: 361 NKLADAVAKIADKM 314

BLAST of CmaCh08G000240 vs. TAIR 10
Match: AT2G33550.1 (Homeodomain-like superfamily protein )

HSP 1 Score: 322.8 bits (826), Expect = 3.6e-88
Identity = 191/374 (51.07%), Postives = 240/374 (64.17%), Query Frame = 0

Query: 1   MALQQLTLGPTPVHAVSDAVTNALDARPISSDGGDNGSKTPRLPRWTRQEILVLIQGKKV 60
           MAL+QL LG +       AV    ++   S+DGGD+G KT RLPRWTRQEILVLIQGK+V
Sbjct: 1   MALEQLGLGVS-------AVDGGENSSAPSNDGGDDGVKTARLPRWTRQEILVLIQGKRV 60

Query: 61  AETRVRGGRAATLAFGSAQLEPKWASVSSYCKRHGVNRGPVQCRKRWSNLAGDFKKIKDW 120
           AE RVR GRAA +A GS Q+EPKWASVSSYCKRHGVNRGPVQCRKRWSNLAGD+KKIK+W
Sbjct: 61  AENRVRRGRAAGMALGSGQMEPKWASVSSYCKRHGVNRGPVQCRKRWSNLAGDYKKIKEW 120

Query: 121 ESQIRDDSESFWVTRNDLRRERKLPGFFDREVYDILESGSAPSPSPTLALALAPAPAPAP 180
           ESQI++++ES+WV RND+RRE+KLPGFFD+EVYDI++ G  P   P L+L LAP      
Sbjct: 121 ESQIKEETESYWVMRNDVRREKKLPGFFDKEVYDIVDGGVIPPAVPVLSLGLAP------ 180

Query: 181 PPPPPPPVPTLTSALNSDDAEPEHVFDSFKTAAADDGLFSDFEQDETSQSPIKEVPGKEA 240
                                           A+D+GL SD ++ E S   +   P  ++
Sbjct: 181 --------------------------------ASDEGLLSDLDRRE-SPEKLNSTPVAKS 240

Query: 241 PVPTLDEEIPAPAPLSEKLYQPASQGC-PDQGTSNERE-AAANPEIGSSLQEGRKRKRMA 300
               +D+E                + C  DQG   E++  AAN E GS+ QE RKRKR +
Sbjct: 241 VTDVIDKE--------------KQEACVADQGRVKEKQPEAANVEGGSTSQEERKRKRTS 300

Query: 301 ------KEGEEESMMVQDELIGILEKNGKLLTAQLEAQNMNFQLDREQRRYHADGLVTVL 360
                 +E E E+  +Q++LI ILE+NG+LL AQLE QN+N +LDREQR+ H D LV VL
Sbjct: 301 FGEKEEEEEEGETKKMQNQLIEILERNGQLLAAQLEVQNLNLKLDREQRKDHGDSLVAVL 314

Query: 361 NKLADALGRIADKL 367
           NKLADA+ +IADK+
Sbjct: 361 NKLADAVAKIADKM 314

BLAST of CmaCh08G000240 vs. TAIR 10
Match: AT2G35640.1 (Homeodomain-like superfamily protein )

HSP 1 Score: 69.3 bits (168), Expect = 7.2e-12
Identity = 47/139 (33.81%), Postives = 68/139 (48.92%), Query Frame = 0

Query: 25  DARPISSDGGDNGSKTPRLPRWTRQEILVLIQGKKVAETRVRGGRAATLAFG-SAQLEPK 84
           DA P  S G     +  R   WT  E LVLI+ KK+ + R R  R+     G +   E +
Sbjct: 3   DADP--SSGEQIVMRECRKGNWTVSETLVLIEAKKMDDQR-RVRRSEKQPEGRNKPAELR 62

Query: 85  WASVSSYCKRHGVNRGPVQCRKRWSNLAGDFKKIKDWE-SQIRDD-----SESFWVTRND 144
           W  +  YC R G  R   QC  +W NL  D+KKI+++E S++        S S+W     
Sbjct: 63  WKWIEEYCWRRGCYRNQNQCNDKWDNLMRDYKKIREYERSRVESSFNTVTSSSYWKMDKT 122

Query: 145 LRRERKLPGFFDREVYDIL 157
            R+E+ LP     ++YD+L
Sbjct: 123 ERKEKNLPSNMLPQIYDVL 138

BLAST of CmaCh08G000240 vs. TAIR 10
Match: AT1G31310.1 (hydroxyproline-rich glycoprotein family protein )

HSP 1 Score: 59.7 bits (143), Expect = 5.7e-09
Identity = 47/166 (28.31%), Postives = 72/166 (43.37%), Query Frame = 0

Query: 42  RLPRWTRQEILVLIQGKKVAETRVRGGRAATLAFGSAQ--------LEPKWASVSSYCKR 101
           R   WT  E +VLI+ K++ + R R  R+  L     Q         E +W  +  YC R
Sbjct: 15  RKGNWTLNETMVLIEAKRMDDER-RMRRSIGLPPPEQQQDIRSNKPAELRWKWIEDYCWR 74

Query: 102 HGVNRGPVQCRKRWSNLAGDFKKIKDWE----------------SQIRDDSESFWVTRND 161
            G  R   QC  +W NL  D+KK++++E                S    ++ S+W     
Sbjct: 75  KGCMRSQNQCNDKWDNLMRDYKKVREYERRRVESSITAGESSSSSAPAGETASYWKMEKS 134

Query: 162 LRRERKLPGFFDREVY----DILESGSAPSPSPTLALALAPAPAPA 180
            R+ER LP     + Y    +++ES + PS +   A+  A A A A
Sbjct: 135 ERKERSLPSNMLPQTYQALFEVVESKTLPSSTAVTAVTAAVAAAAA 179

BLAST of CmaCh08G000240 vs. TAIR 10
Match: AT5G51800.1 (Protein kinase superfamily protein )

HSP 1 Score: 47.0 bits (110), Expect = 3.8e-05
Identity = 54/212 (25.47%), Postives = 85/212 (40.09%), Query Frame = 0

Query: 44  PRWTRQEILVLIQGKKVA-ETRVRGGRAATLAFGSAQLEPKWASVSSYCKRHGVNRGPVQ 103
           P W   E+L L +  +   +T+  G  + ++         K   V+ Y  RHG+NR    
Sbjct: 149 PVWKPNEMLWLARAWRAQYQTQGTGSGSGSVEGRGKTRAEKDREVAEYLNRHGINRDSKI 208

Query: 104 CRKRWSNLAGDFKKIKDWESQIRDD--SESFWVTRNDLRRERKLPGFFDREVYDILESGS 163
              +W N+ G+F+K+ +WE     D   +S++      R++ +LP  FD EVY  L    
Sbjct: 209 AGTKWDNMLGEFRKVYEWEKCGDQDKYGKSYFRLSPYERKQHRLPASFDEEVYQELALFM 268

Query: 164 AP-----------SPSPTLALALAPAPAPAPPPPPPP--------------PVPT----- 222
            P               T+ +A  P    A PPP  P              P+P+     
Sbjct: 269 GPRVRAPTINRGGGGGATVTVASTPPSVEALPPPLYPALMTSRDEYDIENNPIPSIGRGK 328

The following BLAST results are available for this feature:
Match NameE-valueIdentityDescription
Q8VZ205.1e-8751.07Trihelix transcription factor ASR3 OS=Arabidopsis thaliana OX=3702 GN=ASR3 PE=1 ... [more]
Match NameE-valueIdentityDescription
AT2G33550.13.6e-8851.07Homeodomain-like superfamily protein [more]
AT2G35640.17.2e-1233.81Homeodomain-like superfamily protein [more]
AT1G31310.15.7e-0928.31hydroxyproline-rich glycoprotein family protein [more]
AT5G51800.13.8e-0525.47Protein kinase superfamily protein [more]
InterPro
Analysis Name: InterPro Annotations of Cucurbita maxima (Rimu) v1.1
Date Performed: 2021-10-25
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableGENE3D1.10.10.60coord: 46..116
e-value: 9.3E-16
score: 59.7
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 159..305
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 263..280
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 169..191
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 288..305
NoneNo IPR availablePANTHERPTHR47211TRIHELIX TRANSCRIPTION FACTOR ASR3coord: 27..366
NoneNo IPR availablePANTHERPTHR47211:SF2TRIHELIX TRANSCRIPTION FACTOR ASR3coord: 27..366
IPR044822Myb/SANT-like DNA-binding domain 4PFAMPF13837Myb_DNA-bind_4coord: 45..126
e-value: 1.9E-10
score: 41.0
IPR001005SANT/Myb domainPROSITEPS50090MYB_LIKEcoord: 45..111
score: 6.39984

Relationships

The following mRNA feature(s) are a part of this gene:

Feature NameUnique NameType
CmaCh08G000240.1CmaCh08G000240.1mRNA


GO Annotation
GO Assignments
This gene is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0071219 cellular response to molecule of bacterial origin
biological_process GO:0050777 negative regulation of immune response
biological_process GO:0045892 negative regulation of transcription, DNA-templated
cellular_component GO:0005634 nucleus
molecular_function GO:0003677 DNA binding
molecular_function GO:0042803 protein homodimerization activity